Best Natural Supplements for ED: Evidence and Safety Warnings

Korean red ginseng and L-citrulline have small studies for mild ED; many 'male enhancement' products hide prescription drugs. See what's safe and what works.

By the editorial team · Updated Oct 14, 2026 · 4 sources cited

The short answer

The best supplements for ED have modest evidence at most. A Cochrane review found ginseng may slightly improve erectile function, with low certainty. L-citrulline improved erection hardness in a small trial of men with mild ED. Many 'male enhancement' supplements have been found to contain hidden prescription drugs, which can be dangerous. Proven medicines work far better.

Evidence-ranked options

SupplementEvidenceTypical doseNotes
Korean red ginsengCAs studied (often 1,000 mg 3 times a day)Small effects; may interact with blood thinners and diabetes medicines.
L-citrullineC1.5 g a day in a small trialMild ED only; limited data.
'Male enhancement' blendsDAvoidFDA frequently finds hidden sildenafil or tadalafil.

A: strong · B: moderate · C: limited or mixed · D: good evidence of no benefit. See the evidence database.

What helps most

  • See a doctor: ED can signal diabetes, heart disease or hormone problems
  • Exercise, weight loss, not smoking and limiting alcohol all improve erectile function
  • Prescription medicines are effective and safe for most men

Related: libido supplements and testosterone.

Ingredient guides

Frequently asked questions

Is ED a sign of heart disease?

It can be. ED shares risk factors with heart disease, so it's worth a check-up.

Why are hidden drugs in supplements dangerous?

Undeclared sildenafil-type drugs can dangerously lower blood pressure in men taking nitrates for heart conditions.

Sources

  1. Lee HW et al. Ginseng for erectile dysfunction. Cochrane Database Syst Rev. 2021
  2. Cormio L et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011
  3. FDA: Health Fraud Scams
  4. MedlinePlus: Erectile Dysfunction

Educational content, not medical advice. Read our medical disclaimer.

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