Best Supplements for Fertility: For Women and Men Trying to Conceive
Folic acid before conception is essential. Vitamin D, CoQ10 and antioxidants have limited evidence for fertility. See doses and supplements to avoid.
By the editorial team · Updated Oct 14, 2026 · 2 sources cited
The best supplements for fertility start with folic acid: 400 mcg a day before conception prevents neural tube defects, though it doesn't boost fertility itself. Vitamin D, CoQ10 and antioxidants for men's sperm quality have limited, mixed evidence. For PCOS, inositol may help ovulation. Review all supplements with your clinician when trying to conceive.
Evidence-ranked options
| Supplement | Evidence | Typical dose | Notes |
|---|---|---|---|
| Folic acid | A | 400 mcg a day, starting at least 1 month before conception | Prevents neural tube defects. |
| Vitamin D (if low) | C | 600–2,000 IU a day | Low levels linked to poorer outcomes; trials mixed. |
| CoQ10 | C | 200–600 mg in studies | Small studies in egg and sperm quality. |
| Inositol (PCOS) | C | 2–4 g myo-inositol a day | May improve ovulation in PCOS. |
| Men's antioxidant blends | C | As studied | Mixed evidence for live-birth rates. |
A: strong · B: moderate · C: limited or mixed · D: good evidence of no benefit. See the evidence database.
When to seek help
See a fertility specialist after 12 months of trying (6 months if 35 or older), or sooner with irregular periods or known conditions. Related: women's health supplements.
Ingredient guides
Frequently asked questions
When should I start a prenatal vitamin?
At least one month before trying to conceive, ideally three.
Which supplements should I stop when trying to conceive?
High-dose vitamin A, many herbs (including ashwagandha and berberine) and weight-loss products. Ask your clinician.
Sources
Educational content, not medical advice. Read our medical disclaimer.