Lion's Mane Supplements: Benefits, Dosage and Safety
Lion's mane supplements are a popular nootropic. A small trial in older adults with mild cognitive impairment found better cognitive scores while taking it, but the benefit faded after stopping. A 2025 systematic review called the evidence promising but limited.
Evidence at a glance
| Use | Grade | What the research shows |
|---|---|---|
| Mild cognitive impairment | C | One small trial showed improvement that faded after stopping. |
| Memory in healthy adults | C | Mixed results. |
A: strong, consistent human evidence · B: moderate · C: limited or mixed · D: good evidence of no benefit.
Lion's mane is an edible mushroom with a shaggy, white appearance.
How to take it
Take with or without food; see lion's mane before or after food.
Safety and interactions
Generally well tolerated; avoid with mushroom allergy.
Always tell your doctor and pharmacist about the supplements you take. Check combinations with our interaction checker.
Sources
This page is for education and is not a substitute for advice from your doctor. Read our medical disclaimer.